Women’s Health – OvationLab Female Fertility Support (Whole Person Care Protocol) | Fullscript (2025)

Whole person care is a person-centered approach to medicine. It goes beyond treating symptoms or isolated conditions, focusing on the interconnectedness of bodily systems and addressing a wide range of factors. These include biological makeup, behavioral habits, environmental factors, and a patient’s personal beliefs, values, and goals. By tailoring care to align with these unique aspects, healthcare providers can create highly personalized patient plans that address not only physical health but also emotional and mental well-being.

Infertility affects approximately 15% of couples globally and 8.8% of women aged 15–49 in the United States, posing significant emotional, physical, and financial challenges. Addressing this public health issue requires improved access to care, reduced disparities, and more personalized, cost-effective treatments. Key clinical needs include better diagnostics, enhanced emotional support, and greater awareness, with recent surveys confirming that time-to-pregnancy is the most critical factor influencing patient satisfaction.

This template, developed in partnership with OvationLab, aims to provide healthcare providers with practical suggestions for labs, supplements, and lifestyle strategies, helping them design personalized whole person care plans for patients looking to support female fertility.

Advanced lab testing may help identify the root causes of female fertility concerns. By evaluating hormone levels, micronutrient status, and the gut microbiome, providers can uncover imbalances that contribute to symptoms and tailor interventions accordingly.

Evidence-based supplements play a vital role in fertility care by supporting hormonal balance, oocyte quality, and endometrial receptivity, with tailored protocols developed alongside fertility specialists and adjusted throughout the assisted reproductive technology (ART) cycle. Foundational nutrients such as folic acid, B vitamins, vitamin D, omega-3 fatty acids, antioxidants, coenzyme Q10 (CoQ10), myo-inositol, and N-acetyl cysteine (NAC) contribute to improved reproductive outcomes by enhancing cellular energy, reducing oxidative stress, and supporting metabolic and immune functions. Additional supplements—including collagen, probiotics, herbal extracts, and stress-adaptive botanicals—may further benefit fertility by promoting tissue integrity, hormonal regulation, and emotional resilience, although evidence strength varies across compounds.

Lifestyle modifications should be considered first-line interventions for supporting women’s hormones and a healthy reproductive system. Diet, exercise, stress, and sleep directly impact female fertility. (Zhao 2018)(Vitale 2017) Optimizing these factors helps promote overall health and impart a positive benefit on female reproductive health.

This flexible approach ensures a personalized and comprehensive care plan for optimal results.

This protocol offers guidance to help healthcare providers integrate labs, supplements, and lifestyle recommendations into their patient care plans. Start by assessing the patient’s unique needs, goals, and health status. Use the labs section to identify potential areas of focus, such as biomarkers for estrogen dominance or nutrient deficiencies. Finally, incorporate evidence-based supplements and lifestyle strategies to address specific needs and preferences and enhance health outcomes.

• Women under 35: In the absence of urgent medical history or physical findings, evaluation should begin after 12 months of unprotected sex. This allows for the natural conception process while ensuring timely intervention if needed.5,17
• Women over 35: Evaluation is recommended after six months due to the age-related decline in fertility. This earlier evaluation helps maximize the chances of successful fertility treatment. (Practice Committee of the American Society for Reproductive Medicine 2020)(Cristodoro 2024)
• Women over 40: More immediate evaluation and treatment may be warranted due to the significant decline in fertility with advancing age.

Hormone Testing

Quest Diagnostics FSH and LH

Quest Diagnostics FSH and LH in the Fullscript catalog

Quest Diagnostics Testosterone, Free, Bioavailable and Total, MS

Testosterone, Free, Bioavailable and Total, MS in the Fullscript catalog

Quest Diagnostics Estradiol

Quest Diagnostics Estradiol in the Fullscript catalog

Quest Diagnostics Progesterone, LC/MS

Quest Diagnostics Progesterone, LC/MS in the Fullscript catalog

Quest Diagnostics Anti-Mullerian Hormone (AMH), Female

Quest Diagnostics Anti-Mullerian Hormone (AMH), Female in the Fullscript catalog

Quest Diagnostics Thyroid Panel with TSH

Quest Diagnostics Thyroid Panel with TSH in the Fullscript catalog

Quest Diagnostics Thyroglobulin Panel

Quest Diagnostics Thyroglobulin Panel in the Fullscript catalog

Quest Diagnostics Thyroid Peroxidase Antibodies (TPO)

Quest Diagnostics Thyroid Peroxidase Antibodies (TPO) in the Fullscript catalog

Micronutrient Testing

Quest Diagnostics Iron, TIBC, and ferritin panel

Quest Diagnostics Iron, TIBC, and ferritin panel in the Fullscript catalog

Quest Diagnostics Micronutrient, Coenzyme Q10 (CoQ10)

Quest Diagnostics Micronutrient, Coenzyme Q10 (CoQ10) in the Fullscript catalog

Quest Diagnostics Micronutrient, Folate

Quest Diagnostics Micronutrient, Folate in the Fullscript catalog

Quest Diagnostics Micronutrient, Selenium, Blood in the Fullscript catalog

Quest Diagnostics Vitamin D, 25-Hydroxy, Total, Immunoassay

Quest Diagnostics Vitamin D, 25-Hydroxy, Total, Immunoassay in the Fullscript catalog

Quest Diagnostics Vitamin B12 (Cobalamin)

Quest Diagnostics Vitamin B12 (Cobalamin) in the Fullscript catalog

Quest Diagnostics Zinc, RBC in the Fullscript catalog

Quest Diagnostics Metabolic Risk Panel in the Fullscript catalog

Quest Diagnostics Cardio IQ Homocysteine in the Fullscript catalog

Quest Diagnostics Cardio IQ hs-CRP

Quest Diagnostics Cardio IQ hs-CRP in the Fullscript catalog

Quest Diagnostics OmegaCheck

Quest Diagnostics OmegaCheck in the Fullscript catalog

Genova Diagnostics GI Effects® Comprehensive Profile - 3 day in the Fullscript catalog

Doctor’s Data Vaginosis Profile

Doctor's Data Vaginosis Profile in the Fullscript catalog

3X4 Genetics Test + Blueprint Report

3X4 Genetics Test + Blueprint Report in the Fullscript catalog

Prenatal Multivitamin/multimineral (Vitamins, Minerals, Organic Elements)

Dosing: Variable based on ingredient and formulation

Supporting evidence:

• Micronutrient supplementation plays a key role in a whole person care approach to fertility by supporting essential physiological processes required for successful conception and pregnancy.
• Studies have shown that supplementation with multiple micronutrients (MMN), including antioxidants, positively influences clinical outcomes such as fertilization rates, pregnancy rates, and live birth rates in patients undergoing fertility treatments like in-vitro fertilization (IVF) and ovulation induction (OI). (Skoracka 2021)(Alrashidi 2024)
• Patients receiving MMN supplementation during OI have demonstrated significantly higher pregnancy rates and fewer attempts to conceive compared to those relying solely on folic acid supplementation. (Hart 2024)
• This evidence underscores the importance of micronutrient optimization in improving reproductive outcomes for individuals with fertility challenges. (Alrashidi 2024)
  • • Folic acid
      • Folic acid is crucial for DNA synthesis and methylation, which are vital for gene expression modulation and normal cell growth and replication.
      • Adequate folate levels are important for oocyte quality, maturation, fertilization, and implantation.
      • Folic acid might also play a role in homocysteine metabolism, and its supplementation, particularly with vitamin B12, may increase the chances of pregnancy and ART success.
    • B vitamins (B12 and B6)
      • B vitamins are involved in homocysteine metabolism.
      • Vitamin B12 is essential for red blood cell formation, cellular metabolism, and DNA and myelin synthesis.
      • Both folic acid and vitamin B12 are needed for recycling homocysteine to methionine, which is important for S-adenosylmethionine (SAM) production, the primary methyl donor.
    • Iodine
      • Essential for the proper development of the fetus and proper thyroid function, which are crucial during pregnancy. Adequate iodine intake is important for women planning a pregnancy. (Schaefer 2019)
    • Zinc
      • Plays a vital role in regulating ovulation and menstrual cycles by supporting DNA methyltransferases. It is also involved in DNA synthesis and apoptosis. (Schaefer 2019)

Prenatal Multivitamin/multiminerals in the Fullscript catalog

Antioxidants

Dosing: Variable based on ingredient and formulation

Supporting evidence:

• A prospective pilot study investigated the effects of a 90-day oral antioxidant supplementation on ART outcomes in 48 women, compared to 56 historical controls without supplementation. The antioxidant formula included myoinositol, CoQ10, resveratrol, NAC, and various vitamins and minerals. Clinical pregnancy rates were significantly higher in the antioxidant group (54.5% vs. 31.5%). (Rizk 2021)

• CoQ10

• • • CoQ10 acts as a powerful antioxidant and has a key role in cellular bioenergetics by enhancing ATP production. This can improve oocyte quality, ovarian response to stimulation, the follicular environment, and potentially embryonic outcomes, especially in women 35 and older or those with poor ovarian response. (Xu 2018)

• Myo-inositol

• • Myo-inositol plays a role as a second messenger for hormones like follicle-stimulating hormone (FSH), which is crucial for sexual development and reproduction.
  • Myo-inositol has been shown to reduce insulin resistance and androgens and improve ovarian function in women with PCOS, thereby positively influencing clinical pregnancy rates, oocyte quality, and blastocyst development.

• N-Acetylcysteine (NAC)
• • • Acts as a precursor to glutathione, a potent antioxidant, and is a scavenger of reactive oxygen species. By reducing oxidative stress, it can potentially improve oocyte quality and pregnancy outcomes, showing benefits for clinical pregnancy rates in women with polycystic ovary syndrome (PCOS) and potentially live birth rates in specific subgroups.
    • Analysis of 22 studies showed that NAC significantly improved progesterone levels and endometrial thickness in women with PCOS compared to placebo and other drugs, and also increased LH levels when compared to metformin. (Viña 2025)

• Para-amino benzoic acid (PABA), grape seeds, red clover

• • PABA supports optimal blood levels of folic acid. Grape seed has interleukin-6 (IL-6) inhibiting properties (anti-inflammatory). Red clover comprises phytoestrogenic isoflavones, potentially influencing hormonal balance.

Antioxidants in the Fullscript catalog

Collagen

Dosing: 2.5–10 g per day of hydrolyzed collagen peptides

While specific dosing recommendations for collagen in the context of fertility are not yet established, this range is commonly used in clinical studies for other health outcomes.

Supporting evidence:

• Collagen acts as a protein source, supplying essential building blocks for synthesizing proteins involved in reproduction, which are critical for reproductive organ development and healthy fetal growth.
• It provides a unique amino acid profile, helping to address common dietary deficiencies, particularly glycine, which is often lacking in modern diets.
• Key amino acids in collagen include glycine, proline, and hydroxyproline, which:
  • Support the structural integrity of reproductive tissues
  • Aid in oocyte development by regulating cellular metabolism and differentiation
• During pregnancy, additional amino acids such as arginine, leucine, and glutamine play key roles in:
  • Supporting conceptus development
  • Promoting placental growth (Gao 2020)(Shi 2020)(Steele 2022)

Collagen in the Fullscript catalog

Dehydroepiandrosterone (DHEA)

Dosing: 25–75 mg daily for 12 weeks (Xu 2019)

Supporting evidence:

• DHEA is a precursor hormone that may improve ovarian response in women with decreased ovarian reserve undergoing IVF by increasing androgen levels.

DHEA in the Fullscript catalog

Essential Fatty Acids (EFAs)

Dosing: 1,000 mg per day (Trop-Steinberg 2024)

Supporting evidence:

• Omega-3s, which include alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), play a significant role in fertility.
• Consumed through dietary supplements or omega-3-rich foods like fish, omega-3s can enhance reproductive health by reducing inflammation and creating a favorable environment for conception.
• Furthermore, omega-3 intake may reduce the risk of pregnancy loss, thereby increasing the likelihood of live births, making them a valuable component of a comprehensive approach to fertility care. (Shivtia Trop-Steinberg 2024)(Salas-Huetos 2022)

Essential Fatty Acids in the Fullscript catalog

Iron

Dosing: 60–120 mg of iron in the form of a ferrous salt daily for iron-deficient individuals (Stoffel 2020)

Supporting evidence:

• Has roles in mechanisms that could affect fertility, including homocysteine metabolism, inflammation, oxidative stress, and embryogenesis.
• Women with unexplained fertility issues were found to have lower transferrin saturation and mean corpuscular hemoglobin concentration, and were more likely to have ferritin levels below 30µg/L, which may be a factor associated with unexplained fertility issues, suggesting the need for future screening and research on iron deficiency and treatment. (Holzer 2023)
• Women taking iron supplements showed a significantly reduced risk of fertility issues related to ovulation issues, suggesting that iron intake, particularly nonheme iron, may lower the chances of ovulatory infertility. (Chavarro 2006)

Iron in the Fullscript catalog

L-carnitine

Dosing: 250 mg–1 g per day for 12–16 weeks (Agarwal 2018)

Supporting evidence:

• Plays an important role in metabolic and free fatty acid transport, which is crucial for energy production within cells. By enhancing cellular energy balance and reducing oxidative stress, it may improve reproductive function and has shown potential in improving clinical pregnancy rates, particularly in women with clomiphene-resistant PCOS.
• One review highlighted the potential of acetyl-L-carnitine and L-carnitine to improve female fertility by reducing cellular stress, supporting hormonal balance, enhancing energy production, and protecting oocyte integrity, with acetyl-L-carnitine favored for its antioxidant effects and L-carnitine for boosting cellular energy. (Agarwal 2018)
• A 12-week course of 250 mg per day of oral supplementation led to significant reductions in body weight, body mass index (BMI), waist and hip circumference, and improved glycemic control in women with PCOS. (Samimi 2016)

L-carnitine in the Fullscript catalog

Probiotics

Dosing: 10 billion colony-forming units (CFU) per day for six months or until pregnancy is achieved (Favaron 2024)

Supporting evidence:

• Probiotics support fertility care by fostering the immunological balance crucial for successful conception and implantation. A shift from a Th1-dominant to a Th2-predominant environment is essential, involving the reduction of pro-inflammatory cytokines like TNF-α and IFN-ɣ, while increasing anti-inflammatory cytokines like IL-4 and IL-10. This balance mitigates excessive inflammation, creating a favorable environment for embryo implantation.
• Probiotics facilitate this shift, leading to improved implantation outcomes and higher pregnancy rates in women with recurrent implantation failure (RIF). (Kamrani 2025)

Probiotics in the Fullscript catalog

Vitamin D

Dosing: 2,000 IU per day to 4,285 IU per day (or 30,000 IU per week) in patients with hypovitaminosis D (Bezerra Espinola 2020)(Tóth 2025)

Supporting evidence:

• Low serum vitamin D levels have been associated with challenges in reproductive health.
• This hormone has several physiological functions in the female reproductive system, including modulating follicle recruitment through anti-Mullerian hormone regulation and involvement in ovarian and endometrial cell proliferation. It is also vital for hormone regulation, potentially improving sperm quality and ovarian function. Low serum vitamin D has been implicated in infertility.
• Supplementation in women with PCOS and hypovitaminosis D may improve menstrual frequency and metabolic health disturbances. Animal studies suggest its involvement in endometrial, follicular, and embryonic development. (Tóth 2025)
• A prospective, randomized, and controlled pilot trial involved 120 infertile women undergoing IVF. The intervention group (group B) received daily oral supplementation of vitamin D3 (2,000 IU) in combination with myo-inositol, folic acid, and melatonin, starting from the luteal phase. The control group (group A) received the same regimen, excluding vitamin D3. The study found that vitamin D3 supplementation significantly increased both serum vitamin D3 levels and implantation rates compared to the control group (37.1% vs. 19.2%. (Bezerra Espinola 2021)

Vitamin D in the Fullscript catalog

Nutrition

Diet has a major impact on reproductive health through hormone regulation, inflammation control, and nutrient availability for gamete quality and implantation.

Recommendations:

• Mediterranean diet: Boosts ART success; rich in fruits, veggies, fish, nuts, and olive oil
• Anti-inflammatory foods: Limit trans fats and sugars; increase omega-3s
• Blood sugar balance: Choose low-glycemic, whole foods; avoid processed carbs
• Plant-based protein: Include legumes, nuts, seeds; balance with quality animal protein

Micronutrients for fertility:

• • Folate (400 μg): Supports ovulation health
  • Calcium (1 g): Aids fertilization and fetal growth
  • Iron (30–60 mg): Supports implantation and reduces preterm risks
  • Vitamin B12 (50 μg): Enhances implantation
  • Selenium (60 μg): Protects the placenta
  • Zinc (20 mg): Crucial for female fertility
  • Vitamin E (22–30 mg): Supports implantation
  • Vitamin A (370 μg): Aids follicular and uterine function
  • Vitamin C (85 mg): Improves ovarian

Exercise

Exercise improves fertility outcomes like conception and live birth rates, especially with cyclic activities (e.g., walking, cycling). However, studies vary in protocols and outcomes, highlighting the need for standardized guidelines. (Maher 2024)

Recommendations:

• Encourage regular moderate activity: Recommend at least 150 minutes per week of moderate-intensity exercise, such as walking, cycling, or swimming, tailored to the patient’s fitness level and individual needs.
• Incorporate strength training: Advise 2–3 strength training sessions per week to support metabolic health, improve body composition, and promote overall physical resilience.
• Monitor for cycle-related changes: Counsel patients to pay attention to menstrual regularity and adjust exercise intensity or frequency if disruptions occur, particularly in those trying to conceive or managing hormonal health. (Torkel 2024)(Skoracka 2021)(Saftić Martinović 2024)(Malekpour 2023)(Kim 2022)(Xiao 2024)(Mussawar 2023)

Stress Management

Chronic stress, anxiety, and low quality of life can impair fertility by increasing oxidative stress and impacting reproductive health.

Recommendations:

• Recommend daily stress reduction practices: Encourage patients to engage in 10–20 minutes of mindfulness, meditation, or breathwork each day to help regulate stress and support hormonal balance.
• Offer emotional support resources: Refer patients to counseling services, support groups, or evidence-based wellness apps to help manage emotional well-being and reduce feelings of isolation.
• Reframe healthy habits as self-care: Help patients view behaviors like nourishing meals, movement, and rest as acts of self-care rather than obligations, fostering a more sustainable mindset.
• Strengthen relational health: Advise patients on the importance of nurturing their relationship with their partner through intentional quality time and open, supportive communication. (Torkel 2024)(Aitken 2022)(Malekpour 2023)(Hart 2024)(Alrashidi 2024)(Winter 2023)(Schaefer 2019)

Sleep

Sleep patterns and circadian rhythms influence reproductive hormones like melatonin and those from the hypothalamic-pituitary-gonadal axis. Disruptions can negatively affect fertility.

Recommendations:

• • Advise on optimal bedtime: Recommend aiming for sleep before 10:45 p.m., as later bedtimes have been associated with increased risk of fertility challenges and circadian rhythm disruption.
  • Emphasize adequate sleep duration: Encourage patients to prioritize 7–9 hours of quality sleep per night to support reproductive and overall health.
  • Support circadian rhythm alignment: Suggest morning exposure to natural sunlight and limiting blue light exposure in the evening (e.g., from screens) to enhance melatonin production and sleep quality.
  • Optimize the sleep environment: Counsel patients to maintain a cool, dark, and quiet sleep space, and consider using sleep tracking tools to identify patterns or disruptions as needed. (ASRM 2021)(Saftić Martinović 2024)

Environmental Toxins

Exposure to toxins—especially endocrine-disrupting chemicals (EDCs)—can impair hormone balance, gut health, and reproductive function.

Recommendations:

• Educate patients on EDC awareness: Encourage patients to minimize exposure to EDCs by reducing use of plastic containers, limiting processed food intake, and choosing personal care products with safer ingredients.
• Guide toxin reduction strategies: Recommend switching to non-toxic household and personal care products, using water filters, and opting for organic or low-pesticide produce when possible.
• Counsel on substance avoidance: Advise patients to stop smoking, limit alcohol consumption to fewer than two drinks per day, and avoid recreational drug use to support overall health.
• Promote gut health support: Recommend a diet rich in fiber and fermented foods, and assess whether probiotics may be beneficial based on individual needs and clinical context. (Torkel 2024)(Aitken 2022)(Malekpour 2023)(de Santiago 2022)(Hart 2024)(Skakkebæk 2022)(Fabozzi 2022)(Aitken 2024)(Ma 2022)

Patient Resources

• Supporting fertility
• Stress management
• Endocrine disruptors

Disclaimer

The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

View protocol on Fullscript